PreLong Ingredients

St. John’s Wort

St. John’s Wort is a flower with well-studied medicinal effects. 

There has been extensive research on St. John’s Wort, especially on its use in depression.  Like other antidepressants, St. John’s Wort has an impact on sexual function by increasing the level of neurotransmitters (like serotonin) in the brain, but at a different site than typical, synthetic antidepressants.  Research has shown an overall effect of increased time-to-ejaculation, making St. John’s Wort an effective treatment in premature ejaculation.

Other established effects of St. John’s Wort include:

  • Improve sleep at night
  • Topically decrease inflammation in superficial wounds, burns, and hemorrhoids
  • Decrease rheumatic pain, including gout
  • Improve mood in seasonal effective disorder
  • Effective treatment of mild-to-moderate depression


L-citrulline is another compound studied in sexual health and its role as a key precursor of the nitric oxide cycle is well-studied.  Nitric oxide is produced in blood vessels throughout the body and is the principal agent in getting and maintaining an erection.  Increasing the level of L-citrulline can promote the generation of nitric oxide, especially in men with lower levels of nitric oxide production-a common occurrence with age.   


St.  John’s  wort  (SJW)  extracts,  prepared  from  the  aerial  parts  of  Hypericum  perforatum,  contain  numerous  pharmacologically  active  ingredients, including aphthodianthrones (e.g., hypericin and its  derivatives) and phloroglucinols derivatives (e.g., hyperforin).

Hyperforin is a structurally novel anti-depressant isolated from Hypericum perforatum commonly known as St.John’s Wort. Hyperforin used as antidepressants by blocking the reuptake of the neurotransmitters norepinephrine, serotonin, and dopamine.

Recent study found that hyperforin, in high daily doses, is superior to paroxetine as a treatment for even severe depression. Hyperforin is photo and oxygen labile compound that is highly unstable and difficult to isolate in pure form. The standardization of Hypericum perforatum is based on presence of both  Hyperforin and Hypericin. It is designated in percentile, meaning that if a 100mg dose of St. John’s Wort is extracted at a standardized 5%, we will get 5 mg of hyperforin from that dose. However, relevant and, in some cases, life-threatening interactions have been reported, particularly with drugs which are substrate of cytochrome P450 and/or P-glycoprotein.

Adverse effects of St. John’s Wort

Adverse effects of St. John’s Wort are also well-studied.  Side effects, when they occur, are generally mild and include stomach upset, tiredness, headache, dry mouth, dizziness, and skin rash.  It can also increase skin sensitivity to light (photosensitivity).

St. John’s Wort is also known to interact with the cytochrome p-450 (CYP450) system, the body’s primary site of drug break-down.  By increasing the activity of the CYP450, St. John’s Wort can result in increased breakdown of other drugs, decreasing their effectiveness.  This means the herb can result in significant interactions; some of the specific medications St. John’s Wort interacts with include:


Paroxetine (Paxil)

Sertraline (Zoloft)

Venlafaxine (Effexor)

Nefazodone (Serzone)



Cyclosporine (Restasis, Neoral)



Warfarin (Coumadin)


Hyperlipidemia Drugs

Simvastatin (Zocor)



Heart Medications

Nifedipine (Procardia)

Verapamil (Verelan, Calan)


Digoxin (Lanoxin)


Alprazolam (Xanax)

Midazolam (Versed)


Anti-HIV Drugs

Indinavir (Crixivan)


Cancer Drugs

Irinotecan (Camptosar)


Antiepileptic Drugs

Mephenytoin (Mesantoin)


Addiction Medication

Methadone (Dolophine)


Muscle Relaxers

Chlozoxazone (Parafon Forte DSC, Lorzone)


Obstructive Lung Disease Drugs

Theophylline (Elixophyllin, Uniphyl)

Hypoglycemic Drugs

Gliclazide (Diamicron, Dacadis, Nazdol, Zicron)


Drugs Acting on the Gastrointestinal Tract

Omeprazole (Prilosec, Zegerid)



Voriconazole (Vfend)